验证数据展示
经过测试的应用
| Positive WB detected in | mouse liver tissue |
| Positive IHC detected in | human liver tissue, human hepatocirrhosis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
26486-1-AP targets SLC2A9 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, IHC, ELISA Application Description |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag24135 Product name: Recombinant human SLC2A9 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 443-511 aa of BC018897 Sequence: IQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | solute carrier family 2 (facilitated glucose transporter), member 9 |
| 别名 | GLUT9, GLUT-9, GLUTX, Urate transporter |
| 计算分子量 | 540 aa, 59 kDa |
| 观测分子量 | 60 kDa |
| GenBank蛋白编号 | BC018897 |
| 基因名称 | SLC2A9 |
| Gene ID (NCBI) | 56606 |
| RRID | AB_2880532 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9NRM0 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
SLC2A9, also known as GLUT9, is a member of the SLC2A facilitative glucose transporter family. SLC2A9 is mainly expressed in the liver and the kidneys. In the latter organ, SLC2A9 is expressed in the basolateral membranes of proximal renal tubular cells. SLC2A9 is a high-affinity urate transporter and functions in renal urate reabsorption. Mutations in SLC2A9 cause hypouricemia in human subjects.
实验方案
| Product Specific Protocols | |
|---|---|
| IHC protocol for SLC2A9 antibody 26486-1-AP | Download protocol |
| WB protocol for SLC2A9 antibody 26486-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Exp Mol Med Impaired Na+-K+-ATPase signaling in renal proximal tubule contributes to hyperuricemia-induced renal tubular injury. | ||
J Adv Res Punicalagin attenuates hyperuricemia via restoring hyperuricemia-induced renal and intestinal dysfunctions | ||
Pharmacol Res A multi-component intervention enhances intestinal urate excretion and improves metabolic and immune homeostasis in diet-induced hyperuricemia. | ||
NPJ Biofilms Microbiomes Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model | ||
Phytomedicine Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters | ||
Phytomedicine Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice |
