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验证数据展示

  • IHC staining of human colon cancer using 13165-1-AP (same clone as 13165-1-PBS)

    IHC staining of human colon cancer using 13165-1-AP (same clone as 13165-1-PBS)

    Immunohistochemical analysis of paraffin-embedded colon cancer slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 13165-1-AP (same clone as 13165-1-PBS)

    IHC staining of human colon using 13165-1-AP (same clone as 13165-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 13165-1-AP (same clone as 13165-1-PBS)

    IHC staining of human colon using 13165-1-AP (same clone as 13165-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse testis using 13165-1-AP (same clone as 13165-1-PBS)

    IHC staining of mouse testis using 13165-1-AP (same clone as 13165-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse testis using 13165-1-AP (same clone as 13165-1-PBS)

    IHC staining of mouse testis using 13165-1-AP (same clone as 13165-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

SLC26A3 Polyclonal antibody, PBS Only

SLC26A3 Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 13165-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, Indirect ELISA

别名

DRA, Down-regulated in adenoma, CLD, Chloride anion exchanger

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

13165-1-PBS targets SLC26A3 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag3816

Product name: Recombinant human SLC26A3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 497-764 aa of BC025671

Sequence: LTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGKIDFTINTNGGLRNRVYEVPVETKF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 solute carrier family 26, member 3
别名 DRA, Down-regulated in adenoma, CLD, Chloride anion exchanger
计算分子量 764 aa, 85 kDa
观测分子量84 kDa
GenBank蛋白编号BC025671
基因名称 SLC26A3
Gene ID (NCBI) 1811
RRIDAB_3669154
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP40879
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SLC26A3 (Chloride anion exchanger), also known as DRA. It is expected to be located in the cytoplasm and cell membranes. It is a transmembrane glycoprotein, which is mainly located in the lower digestive tract mucosa, especially in the apical membrane of columnar epithelium and some goblet cells. The expression level of SLC26A3 in intestine is different along different parts of intestine, and there are also differences on crypt-villus axis. It is mainly expressed in the apical membrane of colon epithelial cells, less in jejunum and ileum, but not in esophagus. It participates in the absorption of electrically neutral NaCl in intestine and works with Na+/H+ exchanger. Cl-/HCO3- exchange mediated by SLC26A3 is very important for maintaining intestinal acid-base balance. In duodenum, the physiological function of SLC26A3 is related to HCO3- secretion, which plays a central role in neutralizing gastric acid (PMID: 32989468). The molecular weight of SLC26A3 is 84 kDa.

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