验证数据展示
发表文章中的应用
| KD/KO | See 1 publications below |
| WB | See 1 publications below |
产品信息
12242-1-AP targets SLC12A8 in WB, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human |
| 免疫原 |
CatNo: Ag2886 Product name: Recombinant human SLC12A8 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 409-714 aa of BC020506 Sequence: SCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCRSLQSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | solute carrier family 12 (potassium/chloride transporters), member 8 |
| 别名 | Cation-chloride cotransporter 9, CCC9 |
| 计算分子量 | 714 aa, 80 kDa |
| 观测分子量 | 70 KDa |
| GenBank蛋白编号 | BC020506 |
| 基因名称 | SLC12A8 |
| Gene ID (NCBI) | 84561 |
| RRID | AB_3669135 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | A0AV02 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Solute carrier family 12 member 8 (SLC12A8) belongs to the SLC12 gene family, which consists of electroneutral cation-chloride coupled cotransporters. It is highly expressed in small intestine and pancreas and moderately expressed in liver and white adipose tissue (PMID: 31131364). SLC12A8 may be a useful biomarker for the early diagnosis and treatment of bladder cancer (PMID: 33364434).
发表文章
| Species | Application | Title |
|---|---|---|
Nat Commun Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer | ||
Nat Commun Butyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance. | ||
Funct Integr Genomics Integrative analysis and experiment validation of SLC12A8 as a biomarker for the malignant transition from endometriosis to endometriosis associated ovarian cancer.
| ||
Adv Sci (Weinh) Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD(+) Depletion and Osteogenic Decline in Skeletal Aging. |
