• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

    WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67510-1-Ig (SIRT6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

  • WB analysis of Jurkat using 67510-1-Ig (same clone as 67510-1-PBS)

    WB analysis of Jurkat using 67510-1-Ig (same clone as 67510-1-PBS)

    WB result of SIRT6 antibody (67510-1-Ig; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SIRT6 transfected Jurkat cells. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

SIRT6 Monoclonal antibody, PBS Only

SIRT6 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67510-1-PBS

产品说明书

CloneNo. 2H4G8

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse

应用

WB, Indirect ELISA

别名

2H4G8, EC:2.3.1.-, EC:2.3.1.286, EC:2.4.2.-, hSIRT6

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

点击咨询售前客服

点击咨询售后客服

Planning an IHC experiment? We recommend our IHCeasy SIRT6 Ready-To-Use IHC Kit. SIRT6 primary antibody included.

产品信息

67510-1-PBS targets SIRT6 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag24103

Product name: Recombinant human SIRT6 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-328 aa of BC028220

Sequence: MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSNVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
别名 2H4G8, EC:2.3.1.-, EC:2.3.1.286, EC:2.4.2.-, hSIRT6
计算分子量 39 kDa
观测分子量 40 kDa
GenBank蛋白编号BC028220
基因名称 SIRT6
Gene ID (NCBI) 51548
RRIDAB_2882731
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDQ8N6T7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889).