×
Use Able AI chat for product recommendations

验证数据展示

  • IHC staining of human placenta using 27905-1-AP (same clone as 27905-1-PBS)

    IHC staining of human placenta using 27905-1-AP (same clone as 27905-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 27905-1-AP (SH3TC2 antibody) at dilution of 1:100 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27905-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 27905-1-AP (same clone as 27905-1-PBS)

    IHC staining of human placenta using 27905-1-AP (same clone as 27905-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 27905-1-AP (SH3TC2 antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27905-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach cancer using 27905-1-AP (same clone as 27905-1-PBS)

    IHC staining of human stomach cancer using 27905-1-AP (same clone as 27905-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 27905-1-AP (SH3TC2 antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27905-1-PBS in a different storage buffer formulation.

  • IF Staining of U2OS using 27905-1-AP (same clone as 27905-1-PBS)

    IF Staining of U2OS using 27905-1-AP (same clone as 27905-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed U2OS cells using SH3TC2 antibody (27905-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 27905-1-PBS in a different storage buffer formulation.

  • IF Staining of U2OS using 27905-1-AP (same clone as 27905-1-PBS)

    IF Staining of U2OS using 27905-1-AP (same clone as 27905-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using SH3TC2 antibody (27905-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-phalloidin (red). This data was developed using the same antibody clone with 27905-1-PBS in a different storage buffer formulation.

SH3TC2 Polyclonal antibody, PBS Only

SH3TC2 Polyclonal Antibody for IHC, IF/ICC, Indirect ELISA
Cat No. 27905-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, IF/ICC, Indirect ELISA

别名

CMT4C, PP12494, SH3 domain and tetratricopeptide repeat-containing protein 2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

点击咨询售前客服

点击咨询售后客服

产品信息

27905-1-PBS targets SH3TC2 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag27352

Product name: Recombinant human SH3TC2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 254-467 aa of BC113879

Sequence: CGLSRKRDWTGSYQIGRGRCKALTGYEPGEKDELNFYQGESIEIIGFVIPGLQWFIGKSTSSGQVGFVPTRNIDPDSYSPMSRNSAFLSDEERCSLLALGSDKQTECSSFLHTLARTDITSVYRLSGFESIQNPPNDLSASQPEGFKEVRPGRAWEEHQAVGSRQSSSSEDSSLEEELLSATSDSYRLPEPDDLDDPELLMDLSTGQEEEAENF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 SH3 domain and tetratricopeptide repeats 2
别名 CMT4C, PP12494, SH3 domain and tetratricopeptide repeat-containing protein 2
计算分子量 1288 aa, 145 kDa
GenBank蛋白编号BC113879
基因名称 SH3TC2
Gene ID (NCBI) 79628
RRIDAB_3742267
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8TF17
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The SH3TC2 protein (also known as KIAA1985 protein) is an adaptor protein involved in myelin formation in the peripheral nervous system. This protein contains multiple functional domains, including the SH3 (Src homology 3) and TPR (tetratricopeptide repeat) domains, which mediate protein-protein interactions. It is highly expressed in Schwann cells and is crucial for maintaining the stability of myelin structure. Clinically, mutations in the SH3TC2 gene are associated with Charcot-Marie-Tooth disease type 4C (CMT4C), an autosomal recessive peripheral neuropathy characterized by progressive demyelination of motor and sensory nerves, limb weakness, and loss of sensation. Studies have shown that the absence or dysfunction of SH3TC2 protein can lead to disordered signaling pathways in Schwann cells (such as Rab11-mediated membrane transport defects), affecting myelin development and repair.

||
New chat

Able™

正在加载，请稍候...