验证数据展示
产品信息
19746-1-AP targets SH2B2 in ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | SH2B adaptor protein 2 |
| 别名 | APS, SH2B adapter protein 2, SH2B adaptor protein 2, SH2B2 |
| 计算分子量 | 68 kDa |
| GenBank蛋白编号 | NM_020979 |
| 基因名称 | SH2B2 |
| Gene ID (NCBI) | 10603 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O14492 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
SH2B2, also named as APS, belongs to the SH2B adapter family. SH2B2 is an adapter protein for several members of the tyrosine kinase receptor family. It is involved in multiple signaling pathways. SH2B2 may be involved in coupling from immunoreceptor to Ras signaling. SH2B2 acts as a negative regulator of cytokine signaling in collaboration with CBL. SH2B2 binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. It suppresses PDGF-induced mitogenesis. SH2B2 may induce cytoskeletal reorganization via interaction with VAV3.