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验证数据展示

  • WB analysis using 16035-1-AP (same clone as 16035-1-PBS)

    WB analysis using 16035-1-AP (same clone as 16035-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 16035-1-AP (SERPINB2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16035-1-PBS in a different storage buffer formulation.

  • IP experiment of Jurkat using 16035-1-AP (same clone as 16035-1-PBS)

    IP experiment of Jurkat using 16035-1-AP (same clone as 16035-1-PBS)

    IP result of anti-SERPINB2 (IP:16035-1-AP, 4ug; Detection:16035-1-AP 1:300) with Jurkat cells lysate 3600ug. This data was developed using the same antibody clone with 16035-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 16035-1-AP (same clone as 16035-1-PBS)

    IHC staining of mouse brain using 16035-1-AP (same clone as 16035-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 16035-1-AP (SERPINB2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16035-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 16035-1-AP (same clone as 16035-1-PBS)

    IHC staining of mouse brain using 16035-1-AP (same clone as 16035-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 16035-1-AP (SERPINB2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16035-1-PBS in a different storage buffer formulation.

SerpinB2/PAI-2 Polyclonal antibody, PBS Only

SerpinB2/PAI-2 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 16035-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IP, Indirect ELISA

别名

PAI 2, PAI-2, SERPINB2, Monocyte Arg-serpin, PAI2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

16035-1-PBS targets SerpinB2/PAI-2 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag8906

Product name: Recombinant human SERPINB2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-415 aa of BC012609

Sequence: MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKIYSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 serpin peptidase inhibitor, clade B (ovalbumin), member 2
别名 PAI 2, PAI-2, SERPINB2, Monocyte Arg-serpin, PAI2
计算分子量 415 aa, 47 kDa
观测分子量 45-47 kDa
GenBank蛋白编号BC012609
基因名称 SERPINB2
Gene ID (NCBI) 5055
RRIDAB_2186180
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP05120
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SerpinB2, a plasminogen activator inhibitor-2 (PAI-2), is a serine protease inhibitor of the serpin superfamily that inactivates tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) (PMID: 7506655). SerpinB2 may have both pro-tumor and anti-tumor effects. High expression of tumor cell-associated SerpinB2 facilitates breast cancer cell survival and metastasis (PMID: 24581498; PMID: 28427146), while SerpinB2 expression by breast cancer cells significantly inhibits metastasis by inhibiting extracellular uPA (PMID: 24644264; PMID: 28346421).

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