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验证数据展示

  • WB analysis using 87791-1-RR (same clone as 87791-1-PBS)

    WB analysis using 87791-1-RR (same clone as 87791-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87791-1-RR (SDHB antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87791-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 87791-1-RR (same clone as 87791-1-PBS)

    IHC staining of human kidney using 87791-1-RR (same clone as 87791-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 87791-1-RR (SDHB antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87791-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SDHB antibody included

SDHB Recombinant monoclonal antibody, PBS Only

SDHB Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 87791-1-PBS

产品说明书

CloneNo. 253361D1

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

EC:1.3.5.1, Iron-sulfur subunit of complex II, PGL 4, PGL4, SDH

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy SDHB Ready-To-Use IHC Kit. SDHB primary antibody included.

产品信息

87791-1-PBS targets SDHB in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag0968

Product name: Recombinant human SDHB protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-280 aa of BC007840

Sequence: MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
别名 EC:1.3.5.1, Iron-sulfur subunit of complex II, PGL 4, PGL4, SDH
计算分子量 32 kDa
观测分子量 28-32 kDa
GenBank蛋白编号BC007840
基因名称 SDHB
Gene ID (NCBI) 6390
RRIDAB_3745752
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP21912
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SDHB(Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial) is also named as SDH, SDH1 and belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. The SDHD, SDHB, and SDHC genes encode subunits of mitochondrial complex II (succinate dehydrogenase). Mitochondrial complex II is a heterotetrameric complex involved in the aerobic electron transport chain and catalyses the oxidation of succinate to fumarate (Krebs cycle) with transport of electrons to the ubiquinone pool. SDHA and SDHB are the hydrophilic catalytic part of the complex and are highly conserved(J Med Genet 2004;41:e99). Defects in SDHB are a cause of susceptibility to pheochromocytoma (PCC), paragangliomas type 4 (PGL4), paraganglioma and gastric stromal sarcoma (PGGSS) and Cowden-like syndrome (CWDLS).

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