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Species Reactivity
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验证数据展示

  • WB analysis using 85698-1-RR (same clone as 85698-1-PBS)

    WB analysis using 85698-1-RR (same clone as 85698-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85698-1-RR (SCN4A antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85698-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse skeletal muscle using 85698-1-RR (same clone as 85698-1-PBS)

    IHC staining of mouse skeletal muscle using 85698-1-RR (same clone as 85698-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 85698-1-RR (SCN4A antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85698-1-PBS in a different storage buffer formulation.

SCN4A Recombinant antibody, PBS Only

SCN4A Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 85698-1-PBS

产品说明书

CloneNo. 243036A8

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

HYKPP, HYPP, Na(V)1.4, NAC1A, Nav1.4

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

85698-1-PBS targets SCN4A in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 sodium channel, voltage-gated, type IV, alpha subunit
别名 HYKPP, HYPP, Na(V)1.4, NAC1A, Nav1.4
计算分子量 208 kDa
观测分子量208 kDa
GenBank蛋白编号NM_000334
基因名称 SCN4A
Gene ID (NCBI) 6329
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP35499
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Sodium channel protein type 4 subunit alpha (SCN4A, also known as Nav1.4) is the pore-forming subunit of the primary sodium channel present in skeletal muscles (PMID: 16193245). Nav1.4 related channelopathies that affect skeletal muscle excitability are dominant diseases classified in two opposite groups as defined by the prevalent clinical symptoms: muscle stiffness and hypertonia (myotonia) episodes [non dystrophic myotonias (NDM)], and muscle weakness resulting in paralysis episodes (periodic paralyses; PP) (PMID: 20237798; 26285000).