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验证数据展示

  • IP experiment of HEK-293 using 12266-1-AP (same clone as 12266-1-PBS)

    IP experiment of HEK-293 using 12266-1-AP (same clone as 12266-1-PBS)

    IP result of anti-SCAP (IP:12266-1-AP, 4ug; Detection:12266-1-AP 1:600) with HEK-293 cells lysate 1610 ug. This data was developed using the same antibody clone with 12266-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 12266-1-AP (same clone as 12266-1-PBS)

    IHC staining of mouse kidney using 12266-1-AP (same clone as 12266-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 12266-1-AP (SCAP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12266-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 12266-1-AP (same clone as 12266-1-PBS)

    IHC staining of mouse kidney using 12266-1-AP (same clone as 12266-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 12266-1-AP (SCAP antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12266-1-PBS in a different storage buffer formulation.

SCAP Polyclonal antibody, PBS Only

SCAP Polyclonal Antibody for IHC, IP, Indirect ELISA
Cat No. 12266-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, IP, Indirect ELISA

别名

SREBP cleavage-activating protein, SREBP cleavage activating protein, SREBFchaperone, SREBF chaperone, PSEC0227

缓冲液配方: 
偶联物:  Unconjugated
规格价格库存

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产品信息

12266-1-PBS targets SCAP in IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag2937

Product name: Recombinant human SCAP protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 601-905 aa of BC020987

Sequence: LQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 SREBF chaperone
别名 SREBP cleavage-activating protein, SREBP cleavage activating protein, SREBFchaperone, SREBF chaperone, PSEC0227
计算分子量 1279 aa, 140 kDa
观测分子量 140 kDa
GenBank蛋白编号BC020987
基因名称 SCAP
Gene ID (NCBI) 22937
RRIDAB_10697683
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ12770
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SCAP is a regulatory protein that is required for the proteolytic cleavage of the sterol regulatory element-binding protein (SREBP). SCAP is an integral membrane protein located in the endoplasmic reticulum (ER). One of the cytosolic regions of SCAP contains a hexapeptide amino acid sequence, MELADL, that functions to detect cellular cholesterol. When cholesterol is present, SCAP undergoes a conformational change that prevents it from activating SREBP and cholesterol synthesis does not occur. SCAP has 4 isoforms with MW 140, 98, 96 and 85 kDa (refer to UniProt: Q12770).

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