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验证数据展示

  • WB analysis using 86798-1-RR (same clone as 86798-1-PBS)

    WB analysis using 86798-1-RR (same clone as 86798-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86798-1-RR (SAMHD1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86798-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 86798-1-RR (same clone as 86798-1-PBS)

    IF Staining of HepG2 using 86798-1-RR (same clone as 86798-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using SAMHD1 antibody (86798-1-RR, Clone: 251815H5 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 86798-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86798-1-RR

    Affinity and Kinetic Characterization of 86798-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86798-1-RR against Human SAMHD1 were performed. The affinity constant is 0.851 nM.

SAMHD1 Recombinant monoclonal antibody, PBS Only

SAMHD1 Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 86798-1-PBS

产品说明书

CloneNo. 251815H5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

DCIP, Dendritic cell-derived IFNG-induced protein, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, dNTPase, EC:3.1.5.-

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy® SAMHD1 Ready-To-Use IHC Kit. SAMHD1 primary antibody included.

产品信息

86798-1-PBS targets SAMHD1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag3287

Product name: Recombinant human SAMHD1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-315 aa of BC036450

Sequence: MQRADSEQPSKRPRCDDSPRTPSNTPSAEADWSPGLELHPDYKTWGPEQVCSFLRRGGFEEPVLLKNIRENEITGALLPCLDESRFENLGVSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDY

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 SAM domain and HD domain 1
别名 DCIP, Dendritic cell-derived IFNG-induced protein, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, dNTPase, EC:3.1.5.-
计算分子量 626 aa, 72 kDa
观测分子量 64-72 kDa
GenBank蛋白编号BC036450
基因名称 SAMHD1
Gene ID (NCBI) 25939
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9Y3Z3
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SAMHD1, highly expressed by monocytes and monocyte-derived dendritic cells and by monocyte-derived macrophages at a lower extent, is reported as an HIV-1 restriction factor that inhibits the early step of the HIV-1 life cycle. Vpx (virus-like particles containing viral protein X) could overcome this block by interacting with SAMHD1, inducing proteasome-dependent degradation of SAMHD1. Mutations in SAMHD1 cause Aicardi-Goutières syndrome, a genetic encephalopathy with presumed immune pathogenesis. Three alternatively spliced transcripts encoding different isoforms have been described.

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