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验证数据展示

  • WB analysis of THP-1 using 27865-1-AP (same clone as 27865-1-PBS)

    WB analysis of THP-1 using 27865-1-AP (same clone as 27865-1-PBS)

    THP-1 cells were subjected to SDS PAGE followed by western blot with 27865-1-AP (RyDEN antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27865-1-PBS in a different storage buffer formulation.

  • WB analysis using 27865-1-AP (same clone as 27865-1-PBS)

    WB analysis using 27865-1-AP (same clone as 27865-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27865-1-AP (RyDEN antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27865-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 27865-1-AP (same clone as 27865-1-PBS)

    IHC staining of human liver using 27865-1-AP (same clone as 27865-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 27865-1-AP (RyDEN antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27865-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

RyDEN Polyclonal antibody, PBS Only

RyDEN Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 27865-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

C19orf66, Interferon-regulated antiviral protein, IRAV, Repressor of yield of DENV protein, SFL

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

27865-1-PBS targets RyDEN in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag26838

Product name: Recombinant human C19orf66 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-255 aa of BC035817

Sequence: MSQEGVELEKSVRRLREKFHGKVSSKKAGALMRKFGSDHTGVGRSIVYGVKQKDGQELSNDLDAQDPPEDMKQDRDIQAVATSLLPLTEANLRMFQRAQDDLIPAVDRQFACSSCDHVWWRRVPQRKEVSRCRKCRKRYEPVPADKMWGLAEFHCPKCRHNFRTHTHSCSAADCYNRREPHVPGTSCAHPKSRKQNHLPKVLHPSNPHISSGSTVATCLSQGGLLEDLDNLILEDLKEEEEEEEEVEDEEGGPRE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 chromosome 19 open reading frame 66
别名 C19orf66, Interferon-regulated antiviral protein, IRAV, Repressor of yield of DENV protein, SFL
观测分子量 38 kDa
GenBank蛋白编号BC035817
基因名称 C19orf66
Gene ID (NCBI) 55337
RRIDAB_2880997
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9NUL5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The shiftless antiviral inhibitor of ribosomal frameshifting (SHFL) gene was firstly predicted as an ISG in 2011, which is also named as C19orf66, FLJ11286, IRAV, UPF0515, and RyDEN. SHFL showed high expressing level in human liver and spleen tissues, whereas a lower expression is observed in the pancreas and heart. SHFL is a novel ISG that inhibits dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV) infections. Interestingly, SHFL functions as a broad-spectrum antiviral factor exhibiting suppressive activity against various types of RNA and DNA viruses. (PMID: 36293480, PMID: 26735137, PMID: 38149274)

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