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Recombinant Rat AGER/RAGE protein (His Tag)

种属

Rat

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1135

Print datasheet

Synonyms

AGER, RAGE, Advanced glycosylation end product-specific receptor

验证数据展示

  • Purity of Recombinant Rat AGER was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Rat AGER was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Rat AGER protein Gly23-Leu341 (Accession# Q63495) with a His tag at the C-terminus.
基因ID 81722
蛋白编号 Q63495
预测分子量 34.9 kDa
SDS-PAGE 40-45 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Advanced glycosylation end product-specific receptor (AGER, also known as RAGE) is a member of the immunoglobulin superfamily of cell surface receptors, which interacts with distinct families of ligands, mediating diverse functions in a broad array of cell types including cellular migration, proliferation, survival and apoptosis. It senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans. It interacts with distinct molecules implicated in homeostasis, development, inflammation, and certain diseases such as diabetes and Alzheimer's disease.

参考文献:

1.Donato, R. et al. (2003) MICROSC RES TECHNIQ. 60(6):540-51.
2.Yan, SF.et al. (2007) CURR DIABETES REP. 7(2):146-53.
3.Tsoporis, JN. et al. (2010) CIRC RES. 106(1):93-101.
4.Xie, Y. et al. (2017) MOL MED REP. 16(2):1691-1700.
5.Daffu, G. et al. (2015) DIABETES. 64(12):4046-60.