Recombinant Rat Progranulin/PGRN protein (mFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat Progranulin protein Thr18-Leu588 (Accession# P23785) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 29143 |
| 蛋白编号 | P23785 |
| 预测分子量 | 88.1 kDa |
| SDS-PAGE | 85-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Progranulin, also known as Acrogranin, PCDGF, and Epithelin/Granulin Precursor, was first identified as a 593-aa secreted glycoprotein involved in the regulation of cancer progression and wound healing. It is a widely expressed glycoprotein that can undergo proteolysis to generate numerous Granulin peptides. Progranulin (PGRN) has been considered a growth factor-like molecule implicated in additional biological and pathological processes including early embryogenesis, inflammation, host defense, cartilage development and degradation.
参考文献:
1. Yazhou Cui. et al. (2019). Cytokine Growth Factor Rev. 45:53-64. 2. A Bateman. et al. (1990). iochem Biophys Res Commun.173(3):1161-1168. 3. Zhiheng He. et al. (2002). Cancer Res. 62(19):5590-5596. 4. Zhiheng He. et al. (2003). Nat Med. 9(2):225-229. 5. Wei Tang. et al. (2011). Science. 22;332(6028):478-484. 6. Jing Zhu. et al. (2002). Cell. 111(6):867-878. 7. L Díaz-Cueto. et al. (2000). Dev Biol. 217(2):406-418.
