Recombinant Rat Osteopontin protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat Osteopontin protein Leu17-Asn317 (Accession# P087211) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 25353 |
| 蛋白编号 | P08721 |
| 预测分子量 | 59.5 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Osteopontin (OPN), also called secreted phosphoprotein 1 (SPP1), is encoded by the gene SPP1. OPN is a glycoprotein and presents different post-translational modifications according to the tissue of expression. OPN is a multifunctional phosphorylated protein involved in physiological and pathological events. Under physiological conditions, circulating and tissue OPN expression levels are relatively low, and OPN is suggested to play a key role in regulating biomineralization, wound healing, and developmental processes. Under pathological conditions, OPN is often significantly upregulated and exerts pleiotropic effects in several inflammatory, autoimmune, degenerative, fibrosis, and oncologic diseases, such as diabetes, stroke, kidney injury, cardiac fibrosis, and cancers.
参考文献:
1.Lamort AS. et al. (2019) Cells. 8(8):815. 2.Shirakawa K and Sano M. (2021) Biomolecules. 11(7):1047. 3.Yim A. et al. (2022) Immunol Rev. 311(1):224-233. 4.Lin EY. et al. (2023) Int Immunol. 35(4):171-180. 5.Jia Q. et al. (2024) Lung. 202(1):25-39.