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Recombinant Rat IL-1RA protein (rFc Tag)

种属

Rat

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3206

Print datasheet

Synonyms

IL1 inhibitor, IL1RA, Il1rn, IL-1RN, Interleukin-1 receptor antagonist protein

验证数据展示

  • Purity of Recombinant Rat IL-1RA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Rat IL-1RA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Rat IL-1RA protein His27-Gln178 (Accession# P25086) with a rabbit IgG Fc tag at the N-terminus.
基因ID 60582
蛋白编号 P25086
预测分子量 44.6 kDa
SDS-PAGE 45-53 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Interleukin-1 receptor antagonist (IL-1RA) is a critical member of the IL-1 family of cytokines, which plays a significant role in modulating inflammatory responses. IL-1RA exists in two main forms: a secreted form (sIL-1Ra) and an intracellular form (icIL-1Ra). The secreted form is produced by various cells including monocytes, macrophages, neutrophils, and other cells, while the intracellular form is found in keratinocytes and other epithelial cells, as well as in monocytes and fibroblasts. IL-1RA acts as an anti-inflammatory agent by maintaining the balance between pro-inflammatory IL-1α/β and its own anti-inflammatory effects.

参考文献:

1.Arend WP. (2002) Cytokine Growth Factor Rev. 13(4-5):323-340.
2.Spulber S, et al. (2009) Brain Behav Immun. 23(5):573-579. 
3.Gabay C, et al. (2010) Nat Rev Rheumatol. 6(4):232-241. 
4.Akash MS, et al. (2013) Pharm Res. 30(11):2951-2966.