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Recombinant Rat CD44 protein (rFc Tag)

种属

Rat

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1458

Print datasheet

Synonyms

CD44 antigen, ECMR-III, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, Hermes antigen

验证数据展示

  • Purity of Recombinant Rat CD44 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Rat CD44 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Rat CD44 protein Gln22-Glu271 (Accession# O70509) with a rabbit IgG Fc tag at the C-terminus.
基因ID 25406
蛋白编号 O70509
预测分子量 53.3 kDa
SDS-PAGE 62-85 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD44 is a type I transmembrane glycoprotein that mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands. Adhesion with HA plays an important role in cell migration, tumor growth and progression (PMID: 29747682). CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis (PMID: 25941526). CD44 serves as an activation marker distinguishing memory and effector T cells from their naive counterparts. It also plays a role in early T cell signaling events, enhancing T cell receptor signaling (PMID: 26172046). This protein exists in multiple forms generated by alternative RNA splicing and extensive post-translational modifications.

参考文献:

1. Chen C. et al. (2018). J Hematol Oncol. 11(1):64.
2. Gutjahr JC. et al. (2015). Front Immunol. 6:177.
3. Schumann J. et al. (2015). PLoS One. 24;10(11):e0143986.