• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

RYR1 Monoclonal antibody, PBS Only

RYR1 Monoclonal Antibody for Indirect ELISA,IHC

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse

Applications

Indirect ELISA,IHC

Conjugate

Unconjugated

CloneNo.

1B4E12

Cat No : 66539-1-PBS

Print datasheet

Synonyms

CCO, MHS, MHS1, Ryanodine receptor 1, RYDR, RYR, RYR 1, RYR1, SKRR

验证数据展示

  • IHC staining of mouse skeletal muscle using 66539-1-Ig (same clone as 66539-1-PBS)

    IHC staining of mouse skeletal muscle using 66539-1-Ig (same clone as 66539-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 66539-1-Ig (RYR1 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66539-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse skeletal muscle using 66539-1-Ig (same clone as 66539-1-PBS)

    IHC staining of mouse skeletal muscle using 66539-1-Ig (same clone as 66539-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 66539-1-Ig (RYR1 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66539-1-PBS in a different storage buffer formulation.

产品信息

66539-1-PBS targets RYR1 in IHC, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

Tested Applications Indirect ELISA,IHC
Tested Reactivity Human, Mouse
Immunogen RYR1 fusion protein Ag25120 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name ryanodine receptor 1 (skeletal)
Synonyms CCO, MHS, MHS1, Ryanodine receptor 1, RYDR, RYR, RYR 1, RYR1, SKRR
Calculated Molecular Weight 565 kDa
GenBank Accession NumberNM_000540
Gene Symbol RYR1
Gene ID (NCBI) 6261
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle important for excitation-contraction coupling. The transmembrane region of RyR1 is comprised of two domains including the pseudo voltage sensor domain and the pore-forming domain (PMID: 27855725). Dominant RyR1 mutations are the leading cause of MH. Studies on the Ca2+ conducting properties of RyR1 channels containing Malignant hyperthermia mutations expressed in myotubes.