验证数据展示
经过测试的应用
| Positive WB detected in | mouse colon tissue, mouse liver tissue, mouse testis tissue, rat liver tissue, rat testis tissue, rat thymus tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:6000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
29910-1-AP targets RORC in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA Application Description |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 |
CatNo: Ag31783 Product name: Recombinant human RORC protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 165-320 aa of BC031554 Sequence: DLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERC 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | RAR-related orphan receptor C |
| 别名 | NR1F3, Nuclear receptor ROR-gamma, RAR-related orphan receptor C, Retinoid-related orphan receptor-gamma, ROR gamma T |
| 计算分子量 | 518 aa, 58 kDa |
| 观测分子量 | 56 kDa |
| GenBank蛋白编号 | BC031554 |
| 基因名称 | RORC |
| Gene ID (NCBI) | 6097 |
| RRID | AB_2935489 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P51449 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The Nuclear receptors retinoic acid receptor-related orphan receptor gamma (RORγ or RORc, also known as NR1F3) was the third and most recent ROR group member to be discovered, following the prior disclosures of RORα (RORa or NR1F1) and RORβ (RORb or NR1F2) (PMID:24502334). Studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2.RORC has 2 isoforms with the MW of 56 kDa and 58 kDa.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for RORC antibody 29910-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Clin Exp Med Study on the regulation of Treg cell infiltration by EZH2 through CXCR4/CXCL12 in diffuse large B-cell lymphoma. | ||
Respir Res RORγ drives non-small cell lung cancer progression by upregulating the NGF signaling. | ||
Front Immunol The TPx protein of Taenia solium metacestode regulates Treg and Th17 cell differentiation via the TGF-β/Smad signaling pathway. | ||
Adv Sci (Weinh) Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling. | ||
Int Immunopharmacol SLAMF3 promotes Th17 differentiation and is reversed by iguratimod through JAK1/STAT3 pathway in primary Sjögren's syndrome | ||
Immunol Invest MiR-519d-3p from Placenta-Derived Exosomes Induce Immune Intolerance Regulating Immune Cells, Contributing to the Pathogenesis of Preeclampsia |
