验证数据展示
产品信息
27977-1-PBS targets RHNO1 in applications and shows reactivity with human, mouse samples.
| 经测试应用 | IP, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 |
CatNo: Ag14789 Product name: Recombinant human C12orf32 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-241 aa of BC005106 Sequence: HRLMPPRKKRRQPSQKAPLLFHQQPLEGPKHSCASTQLPITHTRQVPSKPIDHSTITSWVSPDFDTAAGSLFPAYQKHQNRARHSSRKPTTSKFPHLTFESPQSSSSETLGIPLIRECPSESEKDVSRRPLVPVLSPQSCGNMSVQALQSLPYVFIPPDIQTPESSSVKEELIPQDQKENSLLSCTLHTGTPNSPEPGPVLVKDTPEDKYGIKVTWRRRQHLLAYLRERGKLSRSQFLVKS 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | chromosome 12 open reading frame 32 |
| 别名 | C12orf32, HKMT1188, HUS1, RAD1, RAD9 |
| 计算分子量 | 238 aa, 27 kDa |
| 观测分子量 | 35 kDa |
| GenBank蛋白编号 | BC005106 |
| 基因名称 | C12orf32 |
| Gene ID (NCBI) | 83695 |
| RRID | AB_3742268 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9BSD3 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
RHNO1 (Rad9-Hus1-Rad1 Interacting Nuclear Orphan 1) is a protein associated with the DNA replication stress (DRS) response and DNA repair. It interacts with the 9-1-1 checkpoint clamp and TopBP1 to activate the ATR/Chk1 signaling pathway, thereby maintaining genomic integrity. Additionally, RHNO1 has been identified as a key facilitator of theta-mediated end joining (TMEJ), a DNA repair mechanism related to cancer progression and chemotherapy resistance. In cancer research, RHNO1 is considered a potential therapeutic target due to its high expression in tumor cells and its regulatory role in cell proliferation and survival.
