验证数据展示
产品信息
60017-1-Ig targets Renin receptor,ATP6AP2 in ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 | Renin receptor,ATP6AP2 fusion protein Ag1360 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | ATPase, H+ transporting, lysosomal accessory protein 2 |
| 别名 | APT6M8 9, ATP6AP2, ATP6IP2, ATP6M8 9, CAPER, ELDF10, HT028, M8 9, MRXE, MSTP009, N14F, PRR, PSEC0072, Renin receptor, RENIN RECEPTOR,ATP6AP2, Renin/prorenin receptor, V ATPase M8.9 subunit, XMRE |
| 计算分子量 | 39 kDa |
| GenBank蛋白编号 | BC010395 |
| 基因名称 | Renin receptor |
| Gene ID (NCBI) | 10159 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | O75787 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ATP6AP2, also named as ATP6IP2, CAPER, ELDF10, N14F, ATP6M8-9, Renin receptor and prorenin receptor, is believed to potentiate the renin-angiotensin system (RAS), conferring to prorenin, a likely pathological role at tissue level. The PRR has been identified in the microvascular endothelial cells of the retina, in which it seems to be involved in pathological neovascularization processes. The present study demonstrates for the first time that the PRR is expressed in human ATP6AP2 and suggests a molecular mechanism by which hypertension may exacerbate the pathology of dry AMD. ATP6AP2 functions as a renin and prorenin cellular receptor. It may mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Defects in ATP6AP2 are a cause of mental retardation X-linked with epilepsy (MRXE). (PMID:19580809)