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验证数据展示

  • WB analysis using 86954-1-RR (same clone as 86954-1-PBS)

    WB analysis using 86954-1-RR (same clone as 86954-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86954-1-RR (RCOR1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86954-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 86954-1-RR (same clone as 86954-1-PBS)

    IF Staining of HeLa using 86954-1-RR (same clone as 86954-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using RCOR1 antibody (86954-1-RR, Clone: 252115G9 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 86954-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86954-1-RR

    Affinity and Kinetic Characterization of 86954-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86954-1-RR against Human RCOR1 were performed. The affinity constant is 1.20 nM.

RCOR1 Recombinant monoclonal antibody, PBS Only

RCOR1 Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 86954-1-PBS

产品说明书

CloneNo. 252115G9

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF/ICC, Indirect ELISA

别名

COREST, RCOR, RCOR 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86954-1-PBS targets RCOR1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag26770

Product name: Recombinant human RCOR1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 245-310 aa of NM_015156

Sequence: MRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 REST corepressor 1
别名 COREST, RCOR, RCOR 1
计算分子量 53 kDa
观测分子量60 kDa
GenBank蛋白编号NM_015156
基因名称 RCOR1
Gene ID (NCBI) 23186
RRIDAB_3745231
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9UKL0
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RCOR1, also named as REST corepressor 1, is a 485 amino acid protein, which belongs to the CoREST family. RCOR1 is a essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. The calculated molecular weight of RCOR1 is a 53 kDa, but the phosphorylated RCOR1 is about 60-65 kDa.

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