验证数据展示
产品信息
55293-1-PBS targets RANK/TNFRSF11A in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
| 别名 | TNFRSF11A, TNR11, Receptor activator of NF-KB, Receptor activator of NF KB, RANK |
| 计算分子量 | 66 kDa |
| 观测分子量 | 80-90 kDa |
| GenBank蛋白编号 | NM_003839 |
| 基因名称 | TNFRSF11A |
| Gene ID (NCBI) | 8792 |
| RRID | AB_3670246 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9Y6Q6 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A, also known as RANK, CD265, and ODFR) is the signaling receptor essential for osteoclast differentiation factor-mediated osteoclastogenesis and is involved in the regulation of interactions between T-cells and dendritic cells (PMID: 9878548). The RANK/RANKL/OPG system is a key regulator in bone resorption, and its dysregulation can lead to pathological bone loss (PMID: 37893470).
