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验证数据展示

  • WB analysis using 87744-1-RR (same clone as 87744-1-PBS)

    WB analysis using 87744-1-RR (same clone as 87744-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87744-1-RR (RAMP3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87744-1-PBS in a different storage buffer formulation.

  • WB analysis of HUVEC using 87744-1-RR (same clone as 87744-1-PBS)

    WB analysis of HUVEC using 87744-1-RR (same clone as 87744-1-PBS)

    WB result of RAMP3 antibody (87744-1-RR; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-RAMP3 transfected HUVEC cells. This data was developed using the same antibody clone with 87744-1-PBS in a different storage buffer formulation.

RAMP3 Recombinant monoclonal antibody, PBS Only

RAMP3 Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 87744-1-PBS

产品说明书

CloneNo. 253174D12

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, Indirect ELISA

别名

Calcitonin-receptor-like receptor activity-modifying protein 3, CRLR activity-modifying protein 3, Receptor activity-modifying protein 3

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87744-1-PBS targets RAMP3 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Eg5467

Product name: Recombinant human RAMP3 protein

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 24-118 aa of NM_005856.3

Sequence: RAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 receptor (G protein-coupled) activity modifying protein 3
别名 Calcitonin-receptor-like receptor activity-modifying protein 3, CRLR activity-modifying protein 3, Receptor activity-modifying protein 3
计算分子量17 kDa
观测分子量 35 kDa
GenBank蛋白编号NM_005856.3
基因名称 RAMP3
Gene ID (NCBI) 10268
RRIDAB_3745728
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDO60896
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The receptor activity-modifying proteins (RAMPs) and the calcitonin receptor-like receptor (CRLR) are both required to generate adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) receptors. During the process, RAMP3 transports the glycosylated CGRPR to the cell surface. The formation of CRLR-RAMP heterodimer is essential for the proper cell surface targeting and pharmacological characteristics of both CGRP and AM receptors. RAMP3 exists in different molecular weight forms: 19 kDa monomer, 35-40 kDa monomer heteroglycosylation, 50 kDa homodimer, and 73 kDa heterodimer (PMID: 19546305).

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