验证数据展示
产品信息
83759-4-PBS targets AGER/RAGE in WB, IF-P, ELISA applications and shows reactivity with rat samples.
| 经测试应用 | WB, IF-P, ELISA Application Description |
| 经测试反应性 | rat |
| 免疫原 |
Fusion Protein 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | advanced glycosylation end product-specific receptor |
| 别名 | RAGE, AGER, Advanced glycosylation end product-specific receptor, 240706F7 |
| 计算分子量 | 43 kDa |
| 观测分子量 | 45 kDa, 58 kDa |
| 基因名称 | Ager |
| Gene ID (NCBI) | 81722 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | Q63495 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Advanced glycosylation end product-specific receptor (AGER, also known as RAGE) is a member of the immunoglobulin superfamily of cell surface receptors, which interacts with distinct families of ligands, mediating diverse functions in a broad array of cell types including cellular migration, proliferation, survival and apoptosis (PMID: 12645002; 17425919). It senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PMID: 19910580; 28627626). It interacts with distinct molecules implicated in homeostasis, development, inflammation, and certain diseases such as diabetes and Alzheimer's disease (PMID: 26253613; 31079281).
