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验证数据展示

  • WB analysis using 19126-1-AP (same clone as 19126-1-PBS)

    WB analysis using 19126-1-AP (same clone as 19126-1-PBS)

    mouse kidney tissue were subjected to SDS PAGE followed by western blot with 19126-1-AP (Polycystin 2 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19126-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 19126-1-AP (same clone as 19126-1-PBS)

    IHC staining of human kidney using 19126-1-AP (same clone as 19126-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 19126-1-AP (Polycystin 2 antibody at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 19126-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 19126-1-AP (same clone as 19126-1-PBS)

    IHC staining of human kidney using 19126-1-AP (same clone as 19126-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 19126-1-AP (Polycystin 2 antibody at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 19126-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse testis using 19126-1-AP (same clone as 19126-1-PBS)

    IP experiment of mouse testis using 19126-1-AP (same clone as 19126-1-PBS)

    IP result of anti-Polycystin 2 (IP:19126-1-AP, 4ug; Detection:19126-1-AP 1:500) with mouse testis tissue lysate 1120 ug. This data was developed using the same antibody clone with 19126-1-PBS in a different storage buffer formulation.

Polycystin 2 Polyclonal antibody, PBS Only

Polycystin 2 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 19126-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat, canine

应用

WB, IHC, IP, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

19126-1-PBS targets Polycystin 2 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat, canine samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat, canine
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 polycystic kidney disease 2 (autosomal dominant)
别名
计算分子量 110 kDa
观测分子量 109 kDa
GenBank蛋白编号NM_000297
基因名称 PKD2
Gene ID (NCBI) 5311
RRIDAB_10641050
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ13563
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Polycystin 2 (PKD2), the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease, belongs to the polycystin family. PKD2 is a ~110-kDa six-transmembrane channel protein with cytoplasmic N- and C-termini. This protein functions as a Ca2+-activated intracellular Ca2+ release channel in the endoplasmic reticulum. It is also present in the plasma membrane, where it functions as a nonselective cation channel. In addition, PKD2 expression has been documented in the primary cilium of kidney epithelial cells, where it is believed to have an essential role in mediating Ca2+ entry in response to flow rate changes, suggesting that it may be part of a mechanosensing machinery residing in the primary cilium. (PMID: 16135816; 10497221)

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