验证数据展示
经过测试的应用
| Positive WB detected in | mouse brain tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:4000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
87061-1-RR targets Phospho-TAU (Ser396/404) in WB, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | microtubule-associated protein tau |
| 别名 | p TAU, p TAU (Ser396/404), p TAU Ser396/404, p -TAU Ser396/404, p -TAU -Ser396/404 |
| 计算分子量 | 37-46, 79-81 kDa |
| 观测分子量 | 45-60 kDa |
| GenBank蛋白编号 | BC000558 |
| 基因名称 | TAU |
| Gene ID (NCBI) | 4137 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P10636 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Tau isolated from individuals with AD is extensively phosphorylated and more than 40 sites have been reported so far. Hyperphosphorylated tau has an impaired ability to stabilize microtubules, and is capable of self-assembling into aggregates that can template normal tau into filaments, making hyperphosphorylation a clear disease-determining posttranslational modification in tauopathies.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for Phospho-TAU (Ser396/404) antibody 87061-1-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
