验证数据展示
产品信息
87129-2-PBS targets Phospho-TAK1 (Ser439) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | mitogen-activated protein kinase kinase kinase 7 |
| 别名 | Phospho TAK1 (Ser412), Phospho-TAK1, Phospho-TAK1 (Ser412), Phospho-TAK1(Ser412), Phospho-TAK1-Ser412 |
| 计算分子量 | 67 kDa |
| 观测分子量 | 75-85 kDa |
| GenBank蛋白编号 | NM_145331 |
| 基因名称 | TAK1 |
| Gene ID (NCBI) | 6885 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | O43318 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
MAP3K7(Mitogen-activated protein kinase kinase kinase 7) is also named TAK1 and belongs to the MAP kinase kinase kinase subfamily. Phospho-TAK1 (Ser439) refers to the phosphorylated form of TAK1 at serine residue 439. TAK1, also known as Transforming Growth Factor-beta activated kinase 1, is a key kinase involved in the regulation of various signaling pathways, including those related to inflammation, immune responses, and cell survival. The phosphorylation of TAK1 at Ser439 is an important post-translational modification that can affect its activity and interaction with other proteins within these pathways. This phosphorylation event is crucial for TAK1's role in signal transduction and its involvement in cellular processes such as the activation of NF-κB and MAPK pathways. It plays a significant role in the activation of downstream signaling cascades that regulate various cellular processes, including cell growth, proliferation, and survival. This antibody is equivalent to Ser412 in mice.
