验证数据展示
经过测试的应用
| Positive WB detected in | mouse brain tissue, rat brain tissue |
This antibody is equivalent to Ser1756 in rat.
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:5000-1:50000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
87294-1-RR targets Phospho-ITPR1 (Ser1764) in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | inositol 1,4,5-triphosphate receptor, type 1 |
| 别名 | Phospho IP3 Receptor (Ser1756), Phospho-IP3 Receptor, Phospho-IP3 Receptor (Ser1756), Phospho-ITPR1, Phospho-ITPR1-Ser1764 |
| 计算分子量 | 314 kDa |
| 观测分子量 | 320 kDa |
| GenBank蛋白编号 | NM_001378452 |
| 基因名称 | ITPR1 |
| Gene ID (NCBI) | 3708 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q14643 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ITPR1, also named as INSP3R1 and IP3R, belongs to the InsP3 receptor family. Phospho-ITPR1 (Thr853) is a phosphorylated form of the inositol-trisphosphate receptor type 1 (ITPR1) protein at threonine residue 853. This phosphorylation site is involved in the regulation of calcium signaling pathways within cells. The specific function and role of Thr853 phosphorylation in ITPR1's activity are not detailed in the provided resources, but phosphorylation events on ITPR1 are known to influence its function, which affects calcium release from the endoplasmic reticulum. Calcium signaling is critical for various cellular processes, including muscle contraction, neurotransmitter release, and cellular division. This antibody is equivalent to Ser1756 in rat.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for Phospho-ITPR1 (Ser1764) antibody 87294-1-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
