验证数据展示
产品信息
87133-1-PBS targets Phospho-ErbB3/HER3 (Tyr1197) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) |
| 别名 | ErbB 3 (phospho Y1197), Her3/ErbB3(phospho-Tyr1197), p-ErbB3/HER3, p-ErbB3/HER3 (Tyr1197), p-ErbB3/HER3(Tyr1197) |
| 计算分子量 | 148 kDa |
| 观测分子量 | 185 kDa |
| GenBank蛋白编号 | NM_001982 |
| 基因名称 | ERBB3 |
| Gene ID (NCBI) | 2065 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P21860 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB-3, HER3) is a member of the EGF receptor tyrosine kinase family including EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4) that are frequently overexpressed in a variety of carcinomas. Phospho-ErbB3/HER3 (Tyr1197) is a phosphorylated form of the epidermal growth factor receptor 3 (EGFR3), also known as HER3. HER3 lacks tyrosine kinase activity itself, but becomes phosphorylated at tyrosine residues after forming heterodimers with other ErbB proteins such as HER2. The HER2/HER3 dimer is a potent activator of growth signaling pathways including MAPK. This phosphorylation event is involved in signal transduction pathways related to cell growth, proliferation, and survival. (PMID: 35625984)
