验证数据展示
产品信息
87795-3-PBS targets Phospho-Beta Arrestin 1 (Ser412) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | arrestin, beta 1 |
| 别名 | Beta Arrestin 1 (Ser412), beta-Arrestin 1 (Ser412), P-Beta Arrestin 1 (Ser412), p-beta-Arrestin 1, p-beta-Arrestin 1 (Ser412) |
| 计算分子量 | 47 kDa |
| 观测分子量 | 50 kDa |
| GenBank蛋白编号 | NM_004041 |
| 基因名称 | Beta Arrestin 1 |
| Gene ID (NCBI) | 408 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P49407 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
β-Arrestins (ARRBs), the best known regulators of G protein-coupled receptor signaling, are versatile and multifunctional adapter proteins that regulate diverse cellular functions, including cell growth, apoptosis and immune responses. Phospho‑β‑arrestin 1 (Ser412) is a key phosphorylated isoform of β‑arrestin 1. Its Ser412 residue is mainly phosphorylated by ERK, governing GPCR desensitization, receptor internalization and downstream signal transduction. This modification regulates β‑arrestin 1 subcellular localization and scaffold function, participating in cell proliferation and insulin‑related ERK signaling desensitization as a vital negative feedback regulator. (PMID: 10347142, PMID: 15520010)
