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验证数据展示

  • WB analysis using 28788-1-AP

    WB analysis using 28788-1-AP

    Non-treated and nocodazole treated SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 28788-1-AP (Phospho-APP (Thr668) antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

Phospho-APP (Thr668) Polyclonal antibody

Phospho-APP (Thr668) Polyclonal Antibody for WB, ELISA
Cat No. 28788-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

Human

应用

WB, ELISA

别名

A4, AAA, ABETA, ABPP, AD1, AICD 50, AICD 57, AICD 59, AID(50), AID(57), AID(59), Amyloid beta A4 protein, amyloid P, amyloid precursor protein, Amyloid-beta precursor protein, APP, APPI, beta Amyloid, CTFgamma, CVAP, Gamma CTF(50) C31, Phospho-APP (Thr668), PN II, PN2, PreA4, Protease nexin II, S APP alpha Soluble APP beta

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格价格库存

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经过测试的应用

Positive WB detected innocodazole treated SH-SY5Y cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:3000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

28788-1-AP targets Phospho-APP (Thr668) in WB, ELISA applications and shows reactivity with Human samples.

经测试应用 WB, ELISA Application Description
经测试反应性 Human
免疫原

fusion protein

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 amyloid beta (A4) precursor protein
别名 A4, AAA, ABETA, ABPP, AD1, AICD 50, AICD 57, AICD 59, AID(50), AID(57), AID(59), Amyloid beta A4 protein, amyloid P, amyloid precursor protein, Amyloid-beta precursor protein, APP, APPI, beta Amyloid, CTFgamma, CVAP, Gamma CTF(50) C31, Phospho-APP (Thr668), PN II, PN2, PreA4, Protease nexin II, S APP alpha Soluble APP beta
观测分子量110 kDa
GenBank蛋白编号BC065529
基因名称 APP
Gene ID (NCBI) 351
RRIDAB_2918202
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP05067
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Amyloid precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain(PMID: 25719338). APP is expressed in many tissues and concentrated in the synapses of neurons. The molecular weight of APP is 100-140 kDa due to the existence of several isoforms. The phosphorylation of APP at Thr668 is involved in the pathogenesis of Alzheimer's disease (AD). The Phospho-APP Thr668 form is neuron‐specific, highly expressed in dystrophic neurites and amyloid plaques of Alzheimer disease, and induces neurodegeneration(PMID: 27076121).

实验方案

Product Specific Protocols
WB protocol for Phospho-APP (Thr668) antibody 28788-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols