验证数据展示
产品信息
87874-1-PBS targets Phospho-ALK (Tyr1278) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | anaplastic lymphoma receptor tyrosine kinase |
| 别名 | ALK (Tyr1278), p-ALK (Tyr1278), pALK Y1278, Phospho-ALK, Phospho-NPM-ALK |
| 计算分子量 | 176 kDa |
| 观测分子量 | 80 kDa, 300 kDa |
| GenBank蛋白编号 | NM_004304 |
| 基因名称 | ALK |
| Gene ID (NCBI) | 238 |
| RRID | AB_3745801 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q9UM73 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Anaplastic lymphoma kinase was first described in 1994 as the NPM-ALK fusion protein that is expressed in the majority of anaplastic large-cell lymphomas. About 2/3rds of anaplastic large-cell lymphomas possess a balanced chromosomal translocation in which the entire nucle-ophosmin (NPM) gene on chromosome 5 is fused to the 3' portion of the ALK gene (including the entire intracellular segment with its protein kinase domain) on chromosome 2. This oncogenic ALK protein kinase is a chimeric protein created by a translocation between chromosomes(2;5)(p23;q35) that generates the NPM-ALK fusion protein. Phospho-ALK (Tyr1278) is a hallmark of ALK-driven malignancies. (PMID: 30400214)
