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验证数据展示

  • WB analysis using 27941-1-AP (same clone as 27941-1-PBS)

    WB analysis using 27941-1-AP (same clone as 27941-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27941-1-AP (PTPRD antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27941-1-PBS in a different storage buffer formulation.

  • WB analysis using 27941-1-AP (same clone as 27941-1-PBS)

    WB analysis using 27941-1-AP (same clone as 27941-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27941-1-AP (PTPRD antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27941-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 27941-1-AP (same clone as 27941-1-PBS)

    IHC staining of human liver using 27941-1-AP (same clone as 27941-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 27941-1-AP (PTPRD antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27941-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 27941-1-AP (same clone as 27941-1-PBS)

    IHC staining of human liver using 27941-1-AP (same clone as 27941-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 27941-1-AP (PTPRD antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27941-1-PBS in a different storage buffer formulation.

PTPRD Polyclonal antibody, PBS Only

PTPRD Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 27941-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

PTPD, Protein-tyrosine phosphatase delta, HPTPD, HPTP DELTA, HPTP

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

27941-1-PBS targets PTPRD in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag27689

Product name: Recombinant human PTPRD protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1089-1225 aa of BC106714

Sequence: GNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 protein tyrosine phosphatase, receptor type, D
别名 PTPD, Protein-tyrosine phosphatase delta, HPTPD, HPTP DELTA, HPTP
计算分子量 1912 aa, 215 kDa
观测分子量75 kDa, 175 kDa
GenBank蛋白编号BC106714
基因名称 PTPRD
Gene ID (NCBI) 5789
RRIDAB_3086013
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP23468
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PTPRD is a receptor-type protein tyrosine phosphatase that plays significant roles in various biological processes, including cell adhesion, synaptic function, and signal transduction. PTPRD is highly expressed in the brain, followed by the kidney, ovary, placenta, and intestine. Within the brain, it is found in specific regions, suggesting a role in neurological functions. PTPRD has emerged as a potential therapeutic target for various brain phenotypes and disorders. Its genetic variations have been associated with nervous system phenotypes, and the discovery of the first small molecule inhibitor of PTPRD phosphatase has opened new avenues for therapeutic intervention in addiction and possibly other PTPRD-associated disorders. Additionally, PTPRD is considered a tumor-suppressor gene that is down-regulated in hepatocellular carcinoma, suggesting its role in cancer progression and potential as a therapeutic target. The protein can recognize 175 kDa full length and 75 kDa mature cleavage product (PMID: 19074898, PMID: 25113440).

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