验证数据展示
产品信息
87561-1-PBS targets PTPN23 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, IF/ICC, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag41272 Product name: Recombinant human PTPN23 protein Source: e coli.-derived, PET30a Tag: 6*His Domain: 420-619 aa of BC004881 Sequence: QEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPSDDPLSLLDPLWTLNKT 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | protein tyrosine phosphatase, non-receptor type 23 |
| 别名 | EC:3.1.3.48, HD PTP, HDPTP, HD-PTP, His domain-containing protein tyrosine phosphatase |
| 计算分子量 | 179 kDa |
| 观测分子量 | 179-200 kDa |
| GenBank蛋白编号 | BC004881 |
| 基因名称 | PTPN23 |
| Gene ID (NCBI) | 25930 |
| RRID | AB_3745624 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q9H3S7 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PTPN23 (Protein Tyrosine Phosphatase Non-receptor Type 23), also known as HD-PTP, is a member of the non-receptor class of protein tyrosine phosphatases that plays a critical role in endosomal trafficking and receptor downregulation. Structurally unique due to its extended C-terminal region containing a Bro1 domain, PTPN23 functions as a core component of the ESCPE-1 (Endosomal SNX-BAR Sorting Complex for Promoting Exit-1) complex and regulates the dephosphorylation of key endosomal proteins, thereby controlling cargo sorting, multivesicular body (MVB) biogenesis, and lysosomal degradation of cell surface receptors such as EGFR. Beyond its role in endocytosis, PTPN23 is involved in ciliogenesis, cell migration, and cytokinesis.
