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验证数据展示

  • WB analysis of mouse liver using 55091-1-AP (same clone as 55091-1-PBS)

    WB analysis of mouse liver using 55091-1-AP (same clone as 55091-1-PBS)

    Mouse liver tissue lysate was subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

  • WB analysis of rat liver using 55091-1-AP (same clone as 55091-1-PBS)

    WB analysis of rat liver using 55091-1-AP (same clone as 55091-1-PBS)

    Rat liver tissue lysate was subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

PTCH2 Polyclonal antibody, PBS Only

PTCH2 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 55091-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, Indirect ELISA

别名

Patched 2, patched homolog 2 (Drosophila), Protein patched homolog 2, PTC2, UNQ560/PRO1121/PRO57079

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

55091-1-PBS targets PTCH2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 patched homolog 2 (Drosophila)
别名 Patched 2, patched homolog 2 (Drosophila), Protein patched homolog 2, PTC2, UNQ560/PRO1121/PRO57079
计算分子量 131 kDa
观测分子量 131-140 kDa
GenBank蛋白编号NM_003738
基因名称 PTCH2
Gene ID (NCBI) 8643
RRIDAB_10858392
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9Y6C5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PTCH1 (patched homolog 1) and PTCH2 are twelve-pass transmembrane proteins that act receptors of Hedgehog signaling pathway (PMID: 8906794; 9811851). Signals of Hedgehog family proteins (SHH, IHH and DHH in humans) are transduced through Patched family receptors (PTCH1 and PTCH2) and Smoothened (SMO) to GLI family transcription factors. Hedgehog pathway plays a critical role in embryonic development and tissue homeostasis, and its dysregulation has been implicated in many human diseases including congenital disorder and cancer (PMID: 23719536; 23532857). PTCH2 may function as a tumor suppressor in the Hedgehog signaling pathway. Alterations in PTCH2 gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. This antibody is specific to PTCH2.

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