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验证数据展示

  • WB analysis using 20124-1-AP (same clone as 20124-1-PBS)

    WB analysis using 20124-1-AP (same clone as 20124-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20124-1-AP (PP4R4 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20124-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 20124-1-AP (same clone as 20124-1-PBS)

    IHC staining of mouse brain using 20124-1-AP (same clone as 20124-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 20124-1-AP (PP4R4 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20124-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 20124-1-AP (same clone as 20124-1-PBS)

    IHC staining of mouse brain using 20124-1-AP (same clone as 20124-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 20124-1-AP (PP4R4 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20124-1-PBS in a different storage buffer formulation.

PP4R4 Polyclonal antibody, PBS Only

PP4R4 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 20124-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

PPP4R4, KIAA1622, Serine/threonine-protein phosphatase 4 regulatory subunit 4

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

20124-1-PBS targets PP4R4 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag13868

Product name: Recombinant human PPP4R4 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-98 aa of BC002650

Sequence: MHPPPPAAAMDFSQNSLFGYMEDLQELTIIERPVRRSLKTPEEIERLTVDEDLSDIERAVYLLSAGQDVQGTSVIANLPFLMRQNPTETLRRVLPKVR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 protein phosphatase 4, regulatory subunit 4
别名 PPP4R4, KIAA1622, Serine/threonine-protein phosphatase 4 regulatory subunit 4
计算分子量 417 aa, 47 kDa
观测分子量 90-100 kDa
GenBank蛋白编号BC002650
基因名称 PP4R4
Gene ID (NCBI) 57718
RRIDAB_3741977
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ6NUP7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PP4R4 (also known as SMEK1) is a regulatory subunit of protein phosphatase 4 (PP4), a serine/threonine phosphatase complex crucial for diverse cellular processes. It plays a key role in directing PP4's activity and substrate specificity, particularly in the DNA damage response, cell cycle progression, and centrosome maturation. Studies highlight its involvement in critical pathways such as ATM/ATR signaling for DNA repair and its regulatory function in cell division. Dysregulation of PP4R4 is implicated in genomic instability and is associated with various diseases, including cancer.

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