验证数据展示
产品信息
15019-1-PBS targets POMGNT1 in IP, Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | IP, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 |
CatNo: Ag7029 Product name: Recombinant human POMGNT1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 313-660 aa of BC001471 Sequence: NYLYRMLRSLLSAQGVSPQMITVFIDGYYEEPMDVVALFGLRGIQHTPISIKNARVSQHYKASLTATFNLFPEAKFAVVLEEDLDIAVDFFSFLSQSIHLLEEDDSLYCISAWNDQGYEHTAEDPALLYRVETMPGLGWVLRRSLYKEELEPKWPTPEKLWDWDMWMRMPEQRRGRECIIPDVSRSYHFGIVGLNMNGYFHEAYFKKHKFNTVPGVQLRNVDSLKKEAYEVEVHRLLSEAEVLDHSKNPCEDSFLPDTEGHTYVAFIRMEKDDDFTTWTQLAKCLHIWDLDVRGNHRGLWRLFRKKNHFLVVGVPASPYSVKKPPSVTPIFLEPPPKEEGAPGAPEQT 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase |
| 别名 | EC:2.4.1.-, GnT I.2, GNTI.2, MEB, MGAT1.2 |
| 计算分子量 | 75 kDa |
| GenBank蛋白编号 | BC001471 |
| 基因名称 | POMGNT1 |
| Gene ID (NCBI) | 55624 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q8WZA1 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
POMGnT1 (Protein O-linked mannose β-1,2-N-acetylglucosaminyltransferase 1) catalyzes the formation of the N-acetylglucosamine β-1,2-Man linkage of O-mannosylglycan, which can increase the protein posttranslational mannosylation level. Defects in POMGNT1 affect neuronal migration and distribution, disrupt basement membranes, and misalign Cajal-Retzius cells (PMID: 36686576). POMGNT1 is mainly enriched in glutamatergic neurons. POMGnT1 is a 660-amino-acid Golgi glycosyltransferase and mainly enriched in glutamatergic neurons. (PMID: 11709191).
