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Conjugate
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Conjugate
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验证数据展示

  • WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    Vairous cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

  • WB analysis of A431 using 66075-1-Ig (same clone as 66075-1-PBS)

    WB analysis of A431 using 66075-1-Ig (same clone as 66075-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

PMS2 Monoclonal antibody, PBS Only

PMS2 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 66075-1-PBS

产品说明书

CloneNo. 1G4E6

宿主/亚型

Mouse / IgG2a

种属反应性

human, mouse, rat

应用

WB, Indirect ELISA

别名

1G4E6, EC:3.1.-.-, HNPCC4, PMS1 protein homolog 2, PMS2CL

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

66075-1-PBS targets PMS2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag12661

Product name: Recombinant human PMS2 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 513-862 aa of BC093921

Sequence: SHCSSEYAASSPGDRGSQEHVDSQEKAPETDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSISSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN

种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
别名 1G4E6, EC:3.1.-.-, HNPCC4, PMS1 protein homolog 2, PMS2CL
计算分子量 862 aa, 96 kDa
观测分子量 100 kDa
GenBank蛋白编号BC093921
基因名称 PMS2
Gene ID (NCBI) 5395
RRIDAB_11182595
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP54278
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PMS2, also named as PMSL2, belongs to the DNA mismatch repair mutL/hexB family. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MLH1 to form MutL alpha. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. It also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. (PMID: 16873062, PMID: 18206974) Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS).