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验证数据展示

  • WB analysis using 67564-1-Ig (same clone as 67564-1-PBS)

    WB analysis using 67564-1-Ig (same clone as 67564-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67564-1-Ig (PICALM antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67564-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 67564-1-Ig (same clone as 67564-1-PBS)

    IHC staining of human lung cancer using 67564-1-Ig (same clone as 67564-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 67564-1-Ig (PICALM antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67564-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with PICALM antibody included
  • IF Staining of HeLa using 67564-1-Ig (same clone as 67564-1-PBS)

    IF Staining of HeLa using 67564-1-Ig (same clone as 67564-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using PICALM antibody (67564-1-Ig, Clone: 1F6G7 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 67564-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 67564-1-Ig (same clone as 67564-1-PBS)

    IF Staining of HepG2 using 67564-1-Ig (same clone as 67564-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using PICALM antibody (67564-1-Ig, Clone: 1F6G7 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 67564-1-PBS in a different storage buffer formulation.

PICALM Monoclonal antibody, PBS Only

PICALM Monoclonal Antibody for WB, IHC, IF/ICC, ELISA
Cat No. 67564-1-PBS

产品说明书

CloneNo. 1F6G7

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, ELISA

别名

1F6G7, CALM, CLTH, LAP, Phosphatidylinositol-binding clathrin assembly protein

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy PICALM Ready-To-Use IHC Kit. PICALM primary antibody included.

产品信息

67564-1-PBS targets PICALM in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag29512

Product name: Recombinant human PICALM protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-356 aa of BC064357

Sequence: MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTT

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 phosphatidylinositol binding clathrin assembly protein
别名 1F6G7, CALM, CLTH, LAP, Phosphatidylinositol-binding clathrin assembly protein
计算分子量 71 kDa
观测分子量 60-70 kDa
GenBank蛋白编号BC064357
基因名称 PICALM
Gene ID (NCBI) 8301
RRIDAB_2882778
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDQ13492
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PICALM (Phosphatidyl Inositol Clathrin Assembly Lymphoid Myeloid protein) is a ubiquitously expressed protein that plays a role in clathrin-mediated endocytosis. PICALM also affects the internalization and trafficking of SNAREs and modulates macroautophagy. PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). The long isoform of human PICALM has 22 exons (encoding PICALML), while the short isoform lacks exon 14 (encoding PICALMS). (PMID: 33397371, PMID: 26075887, PMID: 26005850)

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