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验证数据展示

  • WB analysis of HEK-293 using 66934-1-Ig (same clone as 66934-1-PBS)

    WB analysis of HEK-293 using 66934-1-Ig (same clone as 66934-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 66934-1-Ig (PHEX antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66934-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 66934-1-Ig (same clone as 66934-1-PBS)

    IHC staining of human lung cancer using 66934-1-Ig (same clone as 66934-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 66934-1-Ig (PHEX antibody) at dilution of 1:500 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66934-1-PBS in a different storage buffer formulation.

PHEX Monoclonal antibody, PBS Only

PHEX Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66934-1-PBS

产品说明书

CloneNo. 1D4B2

宿主/亚型

Mouse / IgG1

种属反应性

Human, Rat, Pig

应用

WB, IHC, Indirect ELISA

别名

HPDR, HPDR1, HYP, HYP1, PHEX, XLH

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

66934-1-PBS targets PHEX in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Rat, Pig samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human, Rat, Pig
免疫原 PHEX fusion protein Ag20290 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 phosphate regulating endopeptidase homolog, X-linked
别名 HPDR, HPDR1, HYP, HYP1, PHEX, XLH
计算分子量 749 aa, 86 kDa
观测分子量 86-100 kDa
GenBank蛋白编号BC105059
基因名称 PHEX
Gene ID (NCBI) 5251
RRIDAB_2882259
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP78562
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PHEX encodes a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein usually expressed in osteocytes, osteoblasts and odontoblasts, and it was thought to be involved in bone and dentin mineralization and renal phosphate reabsorption (PMID:28982589). Otherwise, studies showed that PHEX transcripts were identified in human osteosarcoma-derived cells and in differentiated mouse osteoblasts, but not in immature mouse preosteoblasts, indicating the stage-specific expression of the protein (PMID:9199999). Defects in PHEX are responsible for X-linked hypophosphatemic rickets (HYP) (PMID:22339660).Glycosylation of proteins results in higher molecular weight, and about 95-100 kDa band were reported (PMID:25128529; PMID:18728349).