验证数据展示
产品信息
28086-1-PBS targets PEAR1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag27978 Product name: Recombinant human PEAR1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 866-1037 aa of NM_001080471 Sequence: MADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGPFYNKGLISEEELGASVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQRRRQPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYDLPPVRHPPSPPLRRQDR 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | platelet endothelial aggregation receptor 1 |
| 别名 | hPEAR1, JEDI, MEGF12 |
| 计算分子量 | 111 kDa |
| 观测分子量 | 150 kDa |
| GenBank蛋白编号 | NM_001080471 |
| 基因名称 | PEAR1 |
| Gene ID (NCBI) | 375033 |
| RRID | AB_2881056 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q5VY43 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Platelet endothelial aggregation receptor 1 (PEAR1) is a type I transmembrane protein with an EMI domain, 15 epidermal growth factor-like repeats, and multiple cytoplasmic tyrosines and prolines (PMID: 15851471). Highly expressed in endothelial cells and platelets, PEAR1 participates in platelet contact-induced activation. It is required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PMID: 36792666). PEAR1 has also been reported to play roles in the proliferation of activated fibroblasts and myoblasts (PMID: 36402779; 39765730).
