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验证数据展示

  • IF Staining of rat brain using 14075-1-AP (same clone as 14075-1-PBS)

    IF Staining of rat brain using 14075-1-AP (same clone as 14075-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed rat brain tissue using PDGFD antibody (14075-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 14075-1-PBS in a different storage buffer formulation.

  • IF Staining of rat brain using 14075-1-AP (same clone as 14075-1-PBS)

    IF Staining of rat brain using 14075-1-AP (same clone as 14075-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed rat brain tissue using PDGFD antibody (14075-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 14075-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 14075-1-AP (same clone as 14075-1-PBS)

    IHC staining of human colon cancer using 14075-1-AP (same clone as 14075-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 14075-1-AP (PDGF-D antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14075-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach cancer using 14075-1-AP (same clone as 14075-1-PBS)

    IHC staining of human stomach cancer using 14075-1-AP (same clone as 14075-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 14075-1-AP (PDGF-D antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14075-1-PBS in a different storage buffer formulation.

  • IF Staining of A549 using 14075-1-AP (same clone as 14075-1-PBS)

    IF Staining of A549 using 14075-1-AP (same clone as 14075-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A549 cells using PDGFD antibody (14075-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 14075-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

PDGF-D Polyclonal antibody, PBS Only

PDGF-D Polyclonal Antibody for IHC, IF/ICC, IF-P, Indirect ELISA
Cat No. 14075-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

IHC, IF/ICC, IF-P, Indirect ELISA

别名

PDGFD, Iris-expressed growth factor, PDGF D, PDGFD receptor binding form, Platelet-derived growth factor D

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

14075-1-PBS targets PDGF-D in IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 IHC, IF/ICC, IF-P, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原

CatNo: Ag5154

Product name: Recombinant human PDGFD protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-364 aa of BC030645

Sequence: MHRLIFVYTLICANFCSCRDTSATPQSASIKALRNANLRRDDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLEEAENDICRYDFVEVEDISETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSVTDPTLIADALDKKIAEFDTVEDLLKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 platelet derived growth factor D
别名 PDGFD, Iris-expressed growth factor, PDGF D, PDGFD receptor binding form, Platelet-derived growth factor D
计算分子量 43 kDa
GenBank蛋白编号BC030645
基因名称 PDGFD
Gene ID (NCBI) 80310
RRIDAB_2162208
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9GZP0
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Platelet-derived growth factor-D (PDGF-D) is the newest member of the PDGF family. It is secreted as a latent dimer that must undergo extracellular proteolytic removal of its N-terminal CUB domain before the growth-factor domain can activate the β-PDGFR. Once activated, PDGF-D drives proliferation, migration and survival of mesenchymal cells and promotes angiogenesis, wound healing and tissue remodeling. Clinically, PDGF-D is up-regulated in several cancers and in fibrotic diseases of the heart, kidney and lung, making it a potential therapeutic target.

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