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验证数据展示

  • WB analysis using 31730-1-AP (same clone as 31730-1-PBS)

    WB analysis using 31730-1-AP (same clone as 31730-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31730-1-AP (PDE4B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31730-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 31730-1-AP (same clone as 31730-1-PBS)

    IHC staining of mouse brain using 31730-1-AP (same clone as 31730-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 31730-1-AP (PDE4B antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31730-1-PBS in a different storage buffer formulation.

PDE4B Polyclonal antibody, PBS Only

PDE4B Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 31730-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

DPDE4, PDE32, PDE4B5, PDEIVB

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

31730-1-PBS targets PDE4B in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag35552

Product name: Recombinant human PDE4B protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 651-736 aa of BC105040

Sequence: WYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
别名 DPDE4, PDE32, PDE4B5, PDEIVB
计算分子量 736 aa, 83 kDa
观测分子量83 kDa
GenBank蛋白编号BC105040
基因名称 PDE4B
Gene ID (NCBI) 5142
RRIDAB_3670101
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ07343
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PDE4B, also known as DPDE4, is a member of the PDE family of type IV cAMP-specific cyclic nucleotides. PDE4B regulates the cellular concentration of cyclic nucleotides and thus plays a role in signal transduction of inflammatory factors. Among all subtypes of PDE4, PDE4B is closely associated with cancer and has a major contribution to the role in hematological malignancies. PDE4B is distributed in multiple tissues, especially myeloid cells (PMID: 35899614, PMID: 36278172).

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