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验证数据展示

  • WB analysis using 10553-1-AP (same clone as 10553-1-PBS)

    WB analysis using 10553-1-AP (same clone as 10553-1-PBS)

    mouse brain tissue lysates were subjected to SDS PAGE followed by western blot with 10553-1-AP (PCSK2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10553-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 10553-1-AP (same clone as 10553-1-PBS)

    IHC staining of mouse brain using 10553-1-AP (same clone as 10553-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 10553-1-AP (PCSK2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10553-1-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 10553-1-AP (same clone as 10553-1-PBS)

    IHC staining of rat brain using 10553-1-AP (same clone as 10553-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 10553-1-AP (PCSK2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10553-1-PBS in a different storage buffer formulation.

PCSK2 Polyclonal antibody, PBS Only

PCSK2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 10553-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

EC:3.4.21.94, KEX2-like endoprotease 2, NEC2, PC2, SPC2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

10553-1-PBS targets PCSK2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag0852

Product name: Recombinant human PCSK2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 338-638 aa of BC005815

Sequence: GRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 proprotein convertase subtilisin/kexin type 2
别名 EC:3.4.21.94, KEX2-like endoprotease 2, NEC2, PC2, SPC2
计算分子量70.5 kDa
观测分子量 65-75 kDa
GenBank蛋白编号BC005815
基因名称 PCSK2
Gene ID (NCBI) 5126
RRIDAB_2299124
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP16519
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PCSK2(Prohormone convertase 2) is also named as NEC2(neuroendocrine convertase 2), PC2 and belongs to the peptidase S8 family. It is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK2 is responsible for the release of glucagon from proglucagon in pancreatic A cells. This protein has 3 isoforms produced by alternative splicing. PCSK2 is biosynthesized as a 74-kDa inactive precursor which is matured to a 64-kDa active enzyme by autocatalytic removal of its prodomain (PMID: 8397508, 21092739)

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