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验证数据展示

  • IHC staining of human small intestine using 21248-1-AP

    IHC staining of human small intestine using 21248-1-AP

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 21248-1-AP (OSTbeta antibody) at dilution of 1:200 (under 10x lens).

  • IHC staining of human small intestine using 21248-1-AP

    IHC staining of human small intestine using 21248-1-AP

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 21248-1-AP (OSTbeta antibody) at dilution of 1:200 (under 40x lens).

OSTbeta / SLC51B Polyclonal antibody

OSTbeta / SLC51B Polyclonal Antibody for IHC, ELISA
Cat No. 21248-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, ELISA

别名

OST beta, OSTB, OSTbeta, SLC51B

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive IHC detected inhuman small intestine tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

应用推荐稀释比
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

21248-1-AP targets OSTbeta / SLC51B in IHC, ELISA applications and shows reactivity with human samples.

经测试应用 IHC, ELISA Application Description
经测试反应性 human
免疫原 OSTbeta / SLC51B fusion protein Ag15751 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 organic solute transporter beta
别名 OST beta, OSTB, OSTbeta, SLC51B
计算分子量 128 aa, 14 kDa
GenBank蛋白编号BC103842
基因名称 SLC51B
Gene ID (NCBI) 123264
RRIDAB_3085647
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ86UW2
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Organic solute transporter alpha-beta (Ostα-Ostβ) is a heteromeric transporter that has been localized to the basolateral membrane of epithelial cells of the small intestine, kidney and liver, and appears to be essential for bile acid homeostasis. The transporter is composed of a predicted 340-amino acid, 7-transmembrane domain protein (Ostα) and a putative 128-amino acid, single-transmembrane domain polypeptide (Ostβ). Ostα-Ostβ transports bile acids by a facilitated diffusion mechanism; therefore, Ostα-Ostβ can mediate cellular efflux or uptake depending on the substrate's electrochemical gradient. It's reported that Ostα-Ostβ is not only essential for bile acid, but also vital for sterol disposition and enterohepatic circulation(PMID: 21691099).

实验方案

Product Specific Protocols
IHC protocol for OSTbeta / SLC51B antibody 21248-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols