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验证数据展示

  • WB analysis of mouse brain using 14071-1-AP (same clone as 14071-1-PBS)

    WB analysis of mouse brain using 14071-1-AP (same clone as 14071-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 14071-1-AP (NCSTN antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14071-1-PBS in a different storage buffer formulation.

  • IF Staining of C6 using 14071-1-AP (same clone as 14071-1-PBS)

    IF Staining of C6 using 14071-1-AP (same clone as 14071-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed C6 cells using Nicastrin antibody (14071-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 14071-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

Nicastrin Polyclonal antibody, PBS Only

Nicastrin Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 14071-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF/ICC, Indirect ELISA

别名

UNQ1874/PRO4317, NCSTN, KIAA0253

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

14071-1-PBS targets Nicastrin in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag5137

Product name: Recombinant human Nicastrin protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 338-689 aa of BC047621

Sequence: NVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIHARIFLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 nicastrin
别名 UNQ1874/PRO4317, NCSTN, KIAA0253
计算分子量 709 aa, 78.4 kDa
观测分子量 110 kDa
GenBank蛋白编号BC047621
基因名称 Nicastrin
Gene ID (NCBI) 23385
RRIDAB_2149583
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ92542
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Nicastrin (NCT) is a type I transmembrane glycoprotein, which forms high molecular weight gamma-secretase complexes with with presenilin 1 and presenilin 2 (PMID: 16096051). The gamma-secretase is an intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein (APP) and Notch, generating peptide fragments that are important signaling components (PMID: 16096062). The proteolytical processing of APP results in the release of amyloid-βpeptide, a principal component of the plaques found in the brains of Alzheimer's disease patients (PMID: 12716934).

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