验证数据展示
69518-1-Ig
产品信息
69518-1-PBS targets IL-10 in applications and shows reactivity with human samples.
| 经测试应用 | ELISA, Non-Neutralization Application Description |
| 经测试反应性 | human |
| 免疫原 | human Humankine IL-10 protein HZ-1145 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | interleukin 10 |
| 别名 | IL-10, IL-10,IL10, 6C6E6, CSIF, IL 10 |
| 基因名称 | IL-10 |
| Gene ID (NCBI) | 3586 |
| 偶联类型 | Unconjugated |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P22301 |
| 储存缓冲液 | PBS Only, pH 7.4. |
| 储存 | Store at -80°C. |
背景介绍
The human IL10 gene is 4.7 kb in size and is located on the long arm of chromosome 1. It contains five exons. Biologically functional IL-10 exists in the form of a 36 kDa homodimer composed of two non-covalently bonded mono-mers each with 160 amino acids length. IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
This antibody is a neutralizing control antibody for IL-10, the immunogen is the same as Neutrakine 69018-1-Ig but could not neutralize human IL-10.