验证数据展示
69527-1-Ig
产品信息
69527-1-PBS targets HGF in applications and shows reactivity with human samples.
经测试应用 | ELISA, Non-Neutralization Application Description |
经测试反应性 | human |
免疫原 | human Humankine HGF protein HZ-1084 种属同源性预测 |
宿主/亚型 | Mouse / IgG2a |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | hepatocyte growth factor (hepapoietin A; scatter factor) |
别名 | HGF, HGF Alpha, 2G4G8, Hepatocyte growth factor, Hepatocyte growth factor alpha chain |
基因名称 | HGF |
Gene ID (NCBI) | 3082 |
偶联类型 | Unconjugated |
纯化方式 | Protein A purification |
UNIPROT ID | P14210 |
储存缓冲液 | PBS Only, pH 7.4. |
储存 | Store at -80°C. |
背景介绍
Hepatocyte growth factor (HGF) is the most potent mitogen of mature hepatocytes in primary culture. HGF is derived from a biologically inactive single chain precursor of 728 amino acids (pro-HGF) localized mostly on the cell surface and in the extracellular matrix. The mature form produced following proteolytic cleavage is composed of a 69-kDa α-subunit (containing four kringle domains) and the 34 kDa β-subunit, similar to the catalytic domain of serine proteases, but with amino acid substitutions in the active site. HGF is a pleiotropic cytokine which exerts a variety of effects on several cells, being involved in the regulation of many biological processes, such as inflammation, tissue repair, morphogenesis, angiogenesis, tumour propagation, immunomodulation of viral infections and cardio-metabolic activities.
This antibody is a neutralizing control antibody for HGF, the immunogen is the same as Neutrakine 69027-1-Ig but could not neutralize human HGF.