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验证数据展示

  • WB analysis of mouse brain using 55129-1-AP (same clone as 55129-1-PBS)

    WB analysis of mouse brain using 55129-1-AP (same clone as 55129-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 55129-1-AP (Neurabin 2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55129-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 55129-1-AP (same clone as 55129-1-PBS)

    IP experiment of mouse brain using 55129-1-AP (same clone as 55129-1-PBS)

    IP result of anti-Neurabin 2 (IP:55129-1-AP, 4ug; Detection:55129-1-AP 1:300) with mouse brain tissue lysate 6000ug. This data was developed using the same antibody clone with 55129-1-PBS in a different storage buffer formulation.

  • IHC staining of human brain using 55129-1-AP (same clone as 55129-1-PBS)

    IHC staining of human brain using 55129-1-AP (same clone as 55129-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain using 55129-1-AP (Neurabin 2 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 55129-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Neurabin 2 antibody included
  • IHC staining of human brain using 55129-1-AP (same clone as 55129-1-PBS)

    IHC staining of human brain using 55129-1-AP (same clone as 55129-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain using 55129-1-AP (Neurabin 2 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 55129-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Neurabin 2 antibody included
  • WB analysis of A549 using 55129-1-AP (same clone as 55129-1-PBS)

    WB analysis of A549 using 55129-1-AP (same clone as 55129-1-PBS)

    WB result of PPP1R9B antibody (55129-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-Neurabin 2 transfected A549 cells. This data was developed using the same antibody clone with 55129-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

Neurabin 2 Polyclonal antibody, PBS Only

Neurabin 2 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 55129-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy Neurabin 2 Ready-To-Use IHC Kit. Neurabin 2 primary antibody included.

产品信息

55129-1-PBS targets Neurabin 2 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 protein phosphatase 1, regulatory (inhibitor) subunit 9B
别名
计算分子量 89 kDa
观测分子量 120-130 kDa
GenBank蛋白编号NM_032595
基因名称 Spinophilin/Neurabin 2
Gene ID (NCBI) 84687
RRIDAB_10837358
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96SB3
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Neurabin 2, also named as Spinophilin, seems to act as a scaffold protein in multiple signaling pathways. It modulates excitatory synaptic transmission and dendritic spine morphology. PPP1R9B binds to actin filaments (F-actin) and shows cross-linking activity. It may play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. PPP1R9B plays a role in regulation of G-protein coupled receptor signaling, including D2Rs and alpha-adrenergic receptors. PPP1R9B probably regulates p70 S6 kinase activity by forming a complex with TIAM. The antibody is specific to PPP1R9B. The predicted molecular weight of spinophilin is 89 kDa, which differs significantly from the apparent MW seen in SDS/PAGE. Both the expressed full-length cDNA and the endogenous protein run at 120-130 kDa. This may be due to an extended conformation and/or low SDS binding capacity. (PMID: 28941770, PMID: 9275233).

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